Events

Anna Schwager (Karpukhina) will defend her PhD thesis on “Epigenomic and 3D-genomic changes in Mantle Cell Lymphoma” on Friday, October 11 14:00 in the Auditorium 62, B2M.

Congratulations to Anna Shmakova for the Medicina Ph.D. thesis award!

The Gustave Roussy Research Days are back on November 9 and 10 at the University of Paris-Saclay (Faculty of Pharmacy).

Anna Shmakova will defend her PhD thesis on “Factors that contribute to B cell oncogenesis in people living with HIV” on Tuesday, October 24 14:00 in the Auditorium Roger Monier, PR2.

Workshop: Electrochemotherapy and Bioelectricity at Gustave Roussy will take placeJune 9, 2023 in Espace Maurice Tubiana, GR Campus. Host of the event: Dr Catherine BRENNER (METSY9018). On the occasion of this meeting, Lluis M. Mir, DRCE at the CNRS, was awarded a medal for his entire career. This event was co-funded by the GS LSH of Paris Saclay University.

Join us for MAC 2023: A Gathering of Experts in Mitochondria Research!

We’re excited to invite you to the city of Coimbra, Portugal, where the world-renowned MAC 2023 conference will take place on November 30 to December 2, 2023.

• Discover the latest developments in the field of mitochondria research and delve into the critical role they play in aging, cancer, and cell biology. Hear from the leading scientists in the field as they present cutting-edge research and share their insights on the latest breakthroughs.
• Participate in an exciting lineup of events, including short talks, flash presentations, and poster sessions. Share your work, network with fellow researchers, and gain a deeper understanding of this important area of study.
• Make the most of your trip and immerse yourself in the rich history and culture of Coimbra. Enjoy a memorable meeting dinner and a guided tour of the historic University of Coimbra, a UNESCO World Heritage site that dates back to 1290.
• Mark your calendars and make your plans to attend MAC 2023. We look forward to seeing you in Coimbra, where the past and future of mitochondria research will come together in one exciting event.

Nuclear phosphoinositides: new players in gene expression

Professor Pavel HOZAK,

Institute of Molecular Genetics,

Prague, Czech Republic,

Invité par Yegor Vassetzky

Processes such as gene expression or DNA repair are compartmentalized within eukaryotic nucleus, and nuclear environment contains dynamic membrane-less sub-compartments whose formation is prevalently driven by phase separation. It Apparently, formation of phase boundaries provides the surface for spatiotemporal control contributing to the high-rate kinetics of crucial processes such as transcription, ribosome maturation, splicing. I will briefly recapitulate the history of my research and devote a majority of my talk to recent findings from our Prague laboratory. findings We discovered the Nuclear Lipid Islets (NLIs) – globular ~100 nm structures containing PI(4,5)P2 (PIP2) at their periphery which associate with key transcription factors, and showed that NLIs are crucial for efficient Polymerase II transcription. To decipher whether the NLIs surface recruits a transcription regulatory proteins through PIP2 molecules in their surface, we employed a proteomic approach based on differential quantitative mass in combination with super-resolution microscopy. We identified more than 300 NLIs-associated proteins belonging to gene expression (53%) and pre-mRNA splicing (33%). Super-resolution microscopy confirmed that some candidate proteins form foci in nucleoplasm and associate with sub-population of NLIs. Further, our bioinformatical analysis of putative NLIs proteins revealed that majority of them contain Intrinsically Disordered Regions (IDRs). IDRs are known features of proteins undergoing phase separation under in vivo and in vitro conditions. Moreover, we found that the vast majority of these proteins contain K/R rich motifs, which were previously shown as recognition sites for phosphoinositide (PIPs) binding. We hypothesize that NLIs may serve as a structural platform integrating RNA Polymerase II transcription and pre-mRNA splicing by attracting proteins which are prone to form liquid-like particles.

Prof. Pavel Hozak graduated at Moscow State University, accomplished his PhD studies at the Charles University in Prague, and continued his research on the connection between nuclear structure and gene expression as a post-doc at the Dunn School of Pathology in Oxford, UK, and also at the Jacques Monod Institute in Paris, INRA Jouy-en-Josas, and at the Vienna University. From 2006 till now, he is leading the Laboratory of Biology of the Cell Nucleus at the Institute of Molecular Genetics of the Czech Academy of Sciences in Prague, and from 2007, he is a full professor at the Charles University. He actively participated in forming the national and European imaging infrastructure, and from 2012, he serves as the director of Czech-BioImaging National Infrastructure for Biological and Medical Imaging. He published 178 original articles cited >5600x. Besides other awards, he received recently the prestigious Wilhelm Bernhard Medal, and became an honorary member of the Italian Histochemical Society.

Target Of Rapamycin (TOR) pathway has an evolutionary conserved role in the control of growth, metabolism, stress response, survival and ageing.

“TOR de France” that will take place in Saint Paul Hôtel, Nice, France on October 5-6 is a unique conference series in the world entirely devoted to field of “Target Of Rapamycin” signaling, nutrition, growth, metabolism, development. The “TOR de France” meeting gathers students, postdocs, research group leaders and medical doctors working on various aspects of TOR biology and the applications in medicine, pharmacology, human health. This multidisplinary approach allows new and fruitful feedback on everyone’s work and have proven to foster innovative collaborations.