Selected publications
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Epstein-Barr virus reactivation induces MYC-IGH spatial proximity and t(8;14) in B cells (Journal of Medical Virology, 2023)
Sall FB, Shmakova A, Karpukhina A, Tsfasman T, Lomov N, Canoy RJ, Boutboul D, Oksenhendler E, Toure AO, Lipinski M, Wiels J, Germini D, Vassetzky Y.
Burkitt lymphoma (BL) is a B cell malignancy associated with the Epstein-Barr virus (EBV). Most BL cases are characterized by a t(8;14) chromosomal translocation involving the MYC oncogene and the immunoglobulin heavy chain gene (IGH). The role of EBV in promoting this translocation remains largely unknown. Here we provide the experimental evidence that EBV reactivation from latency leads to an increase in the proximity between the MYC and IGH loci, otherwise located far away in the nuclear space both in B-lymphoblastoid cell lines and in patients’ B-cells. Specific DNA damage within the MYC locus, followed by the MRE11-dependent DNA repair plays a role in this process. Using a CRISPR/Cas9-based B cell model to induce specific DNA double strand breaks in MYC and IGH loci, we have shown that the MYC-IGH proximity induced by EBV reactivation leads to an increased t(8;14) translocation frequency.
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Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations (Cancer Communications, 2023)
Shmakova A, Lomov N, Viushkov V, Tsfasman T, Kozhevnikova Y, Sokolova D, Pokrovsky V, Syrkina M, Germini D, Rubtsov M, Vassetzky Y.
Chromosomal translocations are formed by erroneous repair of double-stranded breaks (DSBs) via non-homologous end joining (NHEJ). Some genotoxic drugs produce DSBs and thus present a major risk factor for the development of oncogenic chromosomal translocations. The risk factors that interfere with translocation-prone DSB repair, once DSBs are already formed, are obscure, and potential effects of drugs on translocation formation during this step have never been explored. The study of chromosomal translocations is complicated since naturally occurring translocations are rare, and the localization of breakpoints varies from kilobases to hun-dreds of kilobases, which complicates their detection. In contrast, when DSBs are generated at precise loci, the translocation can be easily detected by PCR. We developed CRISPR/Cas9-based cell models with inducible AML1-ETO and MYC-IGH translocations to evaluate the potential of drugs to favor secondary translocations. In our screen, we identified four drugs, methotrexate, ABC, FTC and TAK779, that increased the rate of chromosomal translocations.
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Analysis of genes regulated by DUX4 via oxidative stress reveals potential therapeutic targets for treatment of facioscapulohumeral dystrophy (Redox Biology, 2021)
Karpukhina A, Galkin I, Ma Y, Dib C, Zinovkin R, Pletjushkina O, Chernyak B, Popova E, Vassetzky Y.
Muscles of patients with facioscapulohumeral dystrophy (FSHD) are characterized by sporadic DUX4 expression and oxidative stress which is at least partially induced by DUX4 protein. Nevertheless, targeting oxidative stress with antioxidants has a limited impact on FSHD patients, and the exact role of oxidative stress in the pathology of FSHD, as well as its interplay with the DUX4 expression, remain unclear. Here we set up a screen for genes that are upregulated by DUX4 via oxidative stress with the aim to target these genes rather than the oxidative stress itself. Immortalized human myoblasts expressing DUX4 (MB135-DUX4) have an increased level of reactive oxygen species (ROS) and exhibit differentiation defects which can be reduced by treating the cells with classic (Tempol) or mitochondria-targeted antioxidants (SkQ1). The transcriptome analysis of antioxidant-treated MB135 and MB135-DUX4 myoblasts allowed us to identify 200 genes with expression deregulated by DUX4 but normalized upon antioxidant treatment. Several of these genes, including PITX1, have been already associated with FSHD and/or muscle differentiation. We confirmed that PITX1 was indeed deregulated in MB135-DUX4 cells and primary FSHD myoblasts and revealed a redox component in PITX1 regulation. PITX1 silencing partially reversed the differentiation defects of MB135-DUX4 myoblasts. Our approach can be used to identify and target redox-dependent genes involved in human diseases.
Full publications list
González-Cuevas JA, Argüello R, Florentin M, André FM, Mir LM. Experimental and Theoretical Brownian Dynamics Analysis of Ion Transport During Cellular Electroporation of E. coli Bacteria. Ann Biomed Eng. 2023 Aug 31. doi: 10.1007/s10439-023-03353-4.
Reid KM, Sanchez-Nieto JM, Terrasse S, Faccenda D, Pernaute B, Campanella M, Rodriguez TA, Cobb BS. MicroRNAs Regulate Ca2+ Homeostasis in Murine Embryonic Stem Cells. Cells. 2023 Jul 28;12(15):1957. doi: 10.3390/cells12151957.
Pan Z, Zhang H, Dokudovskaya S. The Role of mTORC1 Pathway and Autophagy in Resistance to Platinum-Based Chemotherapeutics. Int J Mol Sci. 2023 Jun 26;24(13):10651. doi: 10.3390/ijms241310651.
Shmakova A, Vassetzky Y. lncRNA: A new danger for genome integrity. Int J Cancer. 2023 Apr 1;152(7):1288-1289. doi: 10.1002/ijc.34397.
Zapletal E, Vasiljevic T, Busson P, Matijevic Glavan T. Dialog beyond the Grave: Necrosis in the Tumor Microenvironment and Its Contribution to Tumor Growth. Int J Mol Sci. 2023 Mar 9;24(6):5278. doi: 10.3390/ijms24065278.
Chernyavskij DA, Pletjushkina OY, Kashtanova AV, Galkin II, Karpukhina A, Chernyak BV, Vassetzky YS, Popova EN. Mitochondrial Oxidative Stress and Mitophagy Activation Contribute to TNF-Dependent Impairment of Myogenesis. Antioxidants (Basel). 2023 Mar 1;12(3):602. doi: 10.3390/antiox12030602.
Sall FB, Shmakova A, Karpukhina A, Tsfasman T, Lomov N, Canoy RJ, Boutboul D, Oksenhendler E, Toure AO, Lipinski M, Wiels J, Germini D, Vassetzky Y. Epstein-Barr virus reactivation induces MYC-IGH spatial proximity and t(8;14) in B cells. J Med Virol. 2023 Mar;95(3):e28633. doi: 10.1002/jmv.28633.
Xu JX, Zhang R, Huang DJ, Tang Y, Ping LQ, Huang BJ, Huang HQ, Busson P, Li J. Galectin-9 Facilitates Epstein-Barr Virus Latent Infection and Lymphomagenesis in Human B Cells. Microbiol Spectr. 2023 Feb 14;11(1):e0493222. doi: 10.1128/spectrum.04932-22.
Tiukacheva EA, Ulianov SV, Karpukhina A, Razin SV, Vassetzky Y. 3D genome alterations and editing in pathology. Mol Ther. 2023 Apr 5;31(4):924-933. doi: 10.1016/j.ymthe.2023.02.005.
Kapetanakis NI, Busson P. Galectins as pivotal components in oncogenesis and immune exclusion in human malignancies. Front Immunol. 2023 Feb 3;14:1145268. doi: 10.3389/fimmu.2023.1145268.
Canoy RJ, André F, Shmakova A, Wiels J, Lipinski M, Vassetzky Y, Germini D. Easy and robust electrotransfection protocol for efficient ectopic gene expression and genome editing in human B cells. Gene Ther. 2023 Feb;30(1-2):167-171. doi: 10.1038/s41434-020-00194-x.
Nielsen MA, Køster D, Mehta AY, Stengaard-Pedersen K, Busson P, Junker P, Hørslev-Petersen K, Hetland ML, Østergaard M, Hvid M, Leffler H, Kragstrup TW, Cummings RD, Deleuran B. Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts. Cells. 2023 Jan 15;12(2):327. doi: 10.3390/cells12020327.
Shmakova AA, Popov VS, Romanov IP, Khabibullin NR, Sabitova NR, Karpukhina AA, Kozhevnikova YA, Kurilina EV, Tsokolaeva ZI, Klimovich PS, Rubina KA, Vassetzky YS, Semina EV. Urokinase System in Pathogenesis of Pulmonary Fibrosis: A Hidden Threat of COVID-19. Int J Mol Sci. 2023 Jan 10;24(2):1382. doi: 10.3390/ijms24021382.
Shmakova A, Lomov N, Viushkov V, Tsfasman T, Kozhevnikova Y, Sokolova D, Pokrovsky V, Syrkina M, Germini D, Rubtsov M, Vassetzky Y. Cell models with inducible oncogenic translocations allow to evaluate the potential of drugs to favor secondary translocations. Cancer Commun (Lond). 2023 Jan;43(1):154-158. doi: 10.1002/cac2.12370.
Tran BT, Gelin A, Durand S, Texier M, Daste A, Toullec C, Benihoud K, Breuskin I, Gorphe P, Garic F, Brenner C, Le Tourneau C, Fayette J, Niki T, David M, Busson P, Even C. Plasma galectins and metabolites in advanced head and neck carcinomas: evidence of distinct immune characteristics linked to hypopharyngeal tumors. Oncoimmunology. 2022 Dec 17;12(1):2150472. doi: 10.1080/2162402X.2022.2150472.
Viushkov VS, Lomov NA, Rubtsov MA, Vassetzky YS. Visualizing the Genome: Experimental Approaches for Live-Cell Chromatin Imaging. Cells. 2022 Dec 16;11(24):4086. doi: 10.3390/cells11244086.
Nedara K, Reinhardt C, Lebraud E, Arena G, Gracia C, Buard V, Pioche-Durieu C, Castelli F, Colsch B, Bénit P, Rustin P, Albaud B, Gestraud P, Baulande S, Servant N, Deutsch E, Verbavatz JM, Brenner C, Milliat F, Modjtahedi N. Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation. Front Oncol. 2022 Oct 31;12:958155. doi: 10.3389/fonc.2022.958155.
Canoy RJ, Shmakova A, Karpukhina A, Shepelev M, Germini D, Vassetzky Y. Factors That Affect the Formation of Chromosomal Translocations in Cells. Cancers (Basel). 2022 Oct 18;14(20):5110. doi: 10.3390/cancers14205110.
Valyaeva AA, Tikhomirova MA, Potashnikova DM, Bogomazova AN, Snigiryova GP, Penin AA, Logacheva MD, Arifulin EA, Shmakova AA, Germini D, Kachalova AI, Saidova AA, Zharikova AA, Musinova YR, Mironov AA, Vassetzky YS, Sheval EV. Ectopic expression of HIV-1 Tat modifies gene expression in cultured B cells: implications for the development of B-cell lymphomas in HIV-1-infected patients. PeerJ. 2022 Oct 18;10:e13986. doi: 10.7717/peerj.13986.
Merla C, Nardoni M, Scherman M, Petralito S, Caramazza L, Apollonio F, Liberti M, Paolicelli P, Attal-Tretout B, Mir LM. Changes in hydration of liposome membranes exposed to nanosecond electric pulses detected by wide-field Coherent anti-Stokes Raman microspectroscopy. Bioelectrochemistry. 2022 Oct;147:108218. doi: 10.1016/j.bioelechem.2022.108218.
Mellouk A, Hutteau-Hamel T, Legrand J, Safya H, Benbijja M, Mercier-Nomé F, Benihoud K, Kanellopoulos JM, Bobé P. P2X7 purinergic receptor plays a critical role in maintaining T-cell homeostasis and preventing lupus pathogenesis. Front Immunol. 2022 Sep 29;13:957008. doi: 10.3389/fimmu.2022.957008.
Lai HT, Naumova N, Marchais A, Gaspar N, Geoerger B, Brenner C. Insight into the interplay between mitochondria-regulated cell death and energetic metabolism in osteosarcoma. Front Cell Dev Biol. 2022 Aug 22;10:948097. doi: 10.3389/fcell.2022.948097.
Kiseleva E, Serbina O, Karpukhina A, Mouly V, Vassetzky YS. Interaction between mesenchymal stem cells and myoblasts in the context of facioscapulohumeral muscular dystrophy contributes to the disease phenotype. J Cell Physiol. 2022 Aug;237(8):3328-3337. doi: 10.1002/jcp.30789.
Tellado M, Mir LM, Maglietti F. Veterinary Guidelines for Electrochemotherapy of Superficial Tumors. Front Vet Sci. 2022 Jul 27;9:868989. doi: 10.3389/fvets.2022.868989.
Ichim G, Gibert B, Adriouch S, Brenner C, Davoust N, Desagher S, Devos D, Dokudovskaya S, Dubrez L, Estaquier J, Gillet G, Guénal I, Juin PP, Kroemer G, Legembre P, Levayer R, Manon S, Mehlen P, Meurette O, Micheau O, Mignotte B, Nguyen-Khac F, Popgeorgiev N, Poyet JL, Priault M, Ricci JE, Riquet FB, Susin SA, Suzanne M, Vacher P, Walter L, Mollereau B. Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network. Biomolecules. 2022 Jun 28;12(7):901. doi: 10.3390/biom12070901.
Casbolt H, Campanella M. Ca2+ Signalling is a Conserved Game of Contact. Contact (Thousand Oaks). 2022 Jun 9;5:25152564221095961. doi: 10.1177/25152564221095961.
Zakharova VV, Magnitov MD, Del Maestro L, Ulianov SV, Glentis A, Uyanik B, Williart A, Karpukhina A, Demidov O, Joliot V, Vassetzky YS, Mège RM, Piel M, Razin SV, Ait-Si-Ali S. SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties. Nucleic Acids Res. 2022 May 6;50(8):4389-4413. doi: 10.1093/nar/gkac234.
Singh A, Strobbe D, Campanella M. Pyroptosis targeting via mitochondria: An educated guess to innovate COVID-19 therapies. Br J Pharmacol. 2022 May;179(10):2081-2085. doi: 10.1111/bph.15670.
Lai HT, Canoy RJ, Campanella M, Vassetzky Y, Brenner C. Ca2+ Transportome and the Interorganelle Communication in Hepatocellular Carcinoma. Cells. 2022 Feb 26;11(5):815. doi: 10.3390/cells11050815.
Nestić D, Hozić A, Brkljača Z, Butorac A, Pažur K, Jullienne B, Cindrić M, Ambriović-Ristov A, Benihoud K, Majhen D. Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency. Life Sci. 2022 Feb 15;291:120116. doi: 10.1016/j.lfs.2021.120116.
Liu D, Peyre F, Loissell-Baltazar YA, Courilleau D, Lacas-Gervais S, Nicolas V, Jacquet E, Dokudovskaya S, Taran F, Cintrat JC, Brenner C. Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming. Cells. 2022 Jan 29;11(3):474. doi: 10.3390/cells11030474.
Jorapur A, Marshall LA, Jacobson S, Xu M, Marubayashi S, Zibinsky M, Hu DX, Robles O, Jackson JJ, Baloche V, Busson P, Wustrow D, Brockstedt DG, Talay O, Kassner PD, Cutler G. EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22. PLoS Pathog. 2022 Jan 13;18(1):e1010200. doi: 10.1371/journal.ppat.1010200.
Kurnaeva MA, Zalevsky AO, Arifulin EA, Lisitsyna OM, Tvorogova AV, Shubina MY, Bourenkov GP, Tikhomirova MA, Potashnikova DM, Kachalova AI, Musinova YR, Golovin AV, Vassetzky YS, Sheval EV. Molecular Coevolution of Nuclear and Nucleolar Localization Signals inside the Basic Domain of HIV-1 Tat. J Virol. 2022 Jan 12;96(1):e0150521. doi: 10.1128/JVI.01505-21.
Pánisová E, Lünemann A, Bürgler S, Kotur M, Lazarovici J, Danu A, Kaulfuss M, Mietz J, Chijioke O, Münz C, Busson P, Berger C, Ghez D, Azzi T. Reduced frequency of cytotoxic CD56dim CD16+ NK cells leads to impaired antibody-dependent degranulation in EBV-positive classical Hodgkin lymphoma. Cancer Immunol Immunother. 2022 Jan;71(1):13-24. doi: 10.1007/s00262-021-02956-x.
Consales C, Merla C, Benassi B, Garcia-Sanchez T, Muscat A, André FM, Marino C, Mir LM. Biological effects of ultrashort electric pulses in a neuroblastoma cell line: the energy density role. Int J Radiat Biol. 2022;98(1):109-121. doi: 10.1080/09553002.2022.1998704.
Arena G, Modjtahedi N, Kruger R. Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease: the PINK1/CHCHD4 interplay. Neural Regen Res. 2021 Nov;16(11):2222-2224. doi: 10.4103/1673-5374.310679.
Loissell-Baltazar YA, Dokudovskaya S. SEA and GATOR 10 Years Later. Cells. 2021 Oct 8;10(10):2689. doi: 10.3390/cells10102689.
Emanuel O, Liu J, Schartinger VH, Nei WL, Chan YY, Tsang CM, Riechelmann H, Masterson L, Haybaeck J, Oppermann U, Willems SM, Ooft ML, Wollmann G, Howard D, Vanhaesebroeck B, Lund VJ, Royle G, Chua MLK, Lo KW, Busson P, Lechner M. SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target. Cancers (Basel). 2021 Sep 30;13(19):4944. doi: 10.3390/cancers13194944.
Makowska A, Lelabi N, Nothbaum C, Shen L, Busson P, Tran TTB, Eble M, Kontny U. Radiotherapy Combined with PD-1 Inhibition Increases NK Cell Cytotoxicity towards Nasopharyngeal Carcinoma Cells. Cells. 2021 Sep 17;10(9):2458. doi: 10.3390/cells10092458.
Tesse A, André FM, Ragot T. Aluminum particles generated during millisecond electric pulse application enhance adenovirus-mediated gene transfer in L929 cells. Sci Rep. 2021 Sep 6;11(1):17725. doi: 10.1038/s41598-021-96781-y.
Karpukhina A, Galkin I, Ma Y, Dib C, Zinovkin R, Pletjushkina O, Chernyak B, Popova E, Vassetzky Y. Analysis of genes regulated by DUX4 via oxidative stress reveals potential therapeutic targets for treatment of facioscapulohumeral dystrophy. Redox Biol. 2021 Jul;43:102008. doi: 10.1016/j.redox.2021.102008.
Gailliègue FN, Tamošiūnas M, André FM, Mir LM. A Setup for Microscopic Studies of Ultrasounds Effects on Microliters Scale Samples: Analytical, Numerical and Experimental Characterization. Pharmaceutics. 2021 Jun 8;13(6):847. doi: 10.3390/pharmaceutics13060847.
Karpukhina A, Tiukacheva E, Dib C, Vassetzky YS. Control of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Cancer. Trends Mol Med. 2021 Jun;27(6):588-601. doi: 10.1016/j.molmed.2021.03.008.
Dickson-Murray E, Nedara K, Modjtahedi N, Tokatlidis K. The Mia40/CHCHD4 Oxidative Folding System: Redox Regulation and Signaling in the Mitochondrial Intermembrane Space. Antioxidants (Basel). 2021 Apr 12;10(4):592. doi: 10.3390/antiox10040592.
Liu D, Lai HT, Peyre F, Brenner C. Multiple analysis of mitochondrial metabolism, autophagy and cell death. Methods Cell Biol. 2021;164:95-112. doi: 10.1016/bs.mcb.2021.02.001.
Boutary S, Caillaud M, El Madani M, Vallat JM, Loisel-Duwattez J, Rouyer A, Richard L, Gracia C, Urbinati G, Desmaële D, Echaniz-Laguna A, Adams D, Couvreur P, Schumacher M, Massaad C, Massaad-Massade L. Squalenoyl siRNA PMP22 nanoparticles are effective in treating mouse models of Charcot-Marie-Tooth disease type 1 A. Commun Biol. 2021 Mar 9;4(1):317. doi: 10.1038/s42003-021-01839-2.
Baloche V, Rivière J, Tran TBT, Gelin A, Bawa O, Signolle N, Diop MBK, Dessen P, Beq S, David M, Busson P. Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model. Sci Rep. 2021 Mar 4;11(1):5227. doi: 10.1038/s41598-021-84270-1.
Akbay B, Germini D, Bissenbaev AK, Musinova YR, Sheval EV, Vassetzky Y, Dokudovskaya S. HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells. Int J Mol Sci. 2021 Feb 4;22(4):1588. doi: 10.3390/ijms22041588.
Makowska A, Meier S, Shen L, Busson P, Baloche V, Kontny U. Anti-PD-1 antibody increases NK cell cytotoxicity towards nasopharyngeal carcinoma cells in the context of chemotherapy-induced upregulation of PD-1 and PD-L1. Cancer Immunol Immunother. 2021 Feb;70(2):323-336. doi: 10.1007/s00262-020-02681-x.
Ghorbel A, André FM, Mir LM, García-Sánchez T. Electrophoresis-assisted accumulation of conductive nanoparticles for the enhancement of cell electropermeabilization. Bioelectrochemistry. 2021 Feb;137:107642. doi: 10.1016/j.bioelechem.2020.107642.
Ulianov SV, Zakharova VV, Galitsyna AA, Kos PI, Polovnikov KE, Flyamer IM, Mikhaleva EA, Khrameeva EE, Germini D, Logacheva MD, Gavrilov AA, Gorsky AS, Nechaev SK, Gelfand MS, Vassetzky YS, Chertovich AV, Shevelyov YY, Razin SV. Order and stochasticity in the folding of individual Drosophila genomes. Nat Commun. 2021 Jan 4;12(1):41. doi: 10.1038/s41467-020-20292-z.
Meyenberg Cunha-de Padua M, Fabbri L, Dufies M, Lacas-Gervais S, Contenti J, Voyton C, Fazio S, Irondelle M, Mograbi B, Rouleau M, Sadaghianloo N, Rovini A, Brenner C, Craigen WJ, Bourgeais J, Herault O, Bost F, Mazure NM. Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC. Cancers (Basel). 2020 Nov 23;12(11):3484. doi: 10.3390/cancers12113484.
Valyaeva AA, Zharikova AA, Kasianov AS, Vassetzky YS, Sheval EV. Expression of SARS-CoV-2 entry factors in lung epithelial stem cells and its potential implications for COVID-19. Sci Rep. 2020 Oct 20;10(1):17772. doi: 10.1038/s41598-020-74598-5.
Sorokin DV, Arifulin EA, Vassetzky YS, Sheval EV. Live-Cell Imaging and Analysis of Nuclear Body Mobility. Methods Mol Biol. 2020;2175:1-9. doi: 10.1007/978-1-0716-0763-3_1.
Zhang CX, Huang DJ, Baloche V, Zhang L, Xu JX, Li BW, Zhao XR, He J, Mai HQ, Chen QY, Zhang XS, Busson P, Cui J, Li J. Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation. Oncogenesis. 2020 Jul 6;9(7):65. doi: 10.1038/s41389-020-00248-0.
Germini D, Sall FB, Shmakova A, Wiels J, Dokudovskaya S, Drouet E, Vassetzky Y. Oncogenic Properties of the EBV ZEBRA Protein. Cancers (Basel). 2020 Jun 5;12(6):1479. doi: 10.3390/cancers12061479.
Reinhardt C, Arena G, Nedara K, Edwards R, Brenner C, Tokatlidis K, Modjtahedi N. AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165746. doi: 10.1016/j.bbadis.2020.165746.
Baloche V, Ferrand FR, Makowska A, Even C, Kontny U, Busson P. Emerging therapeutic targets for nasopharyngeal carcinoma: opportunities and challenges. Expert Opin Ther Targets. 2020 Jun;24(6):545-558. doi: 10.1080/14728222.2020.1751820.
Shmakova A, Germini D, Vassetzky Y. HIV-1, HAART and cancer: A complex relationship. Int J Cancer. 2020 May 15;146(10):2666-2679. doi: 10.1002/ijc.32730.
Akbay B, Shmakova A, Vassetzky Y, Dokudovskaya S. Modulation of mTORC1 Signaling Pathway by HIV-1. Cells. 2020 Apr 28;9(5):1090. doi: 10.3390/cells9051090.
Pervaiz S, Bellot GL, Lemoine A, Brenner C. Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy. Int Rev Cell Mol Biol. 2020;352:189-214. doi: 10.1016/bs.ircmb.2020.03.002.
Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, Pai TP, Onji M, Uribesalgo I, Hanada R, Kozieradzki I, Koglgruber R, Cronin SJ, She Z, Quehenberger F, Popper H, Kenner L, Haigh JJ, Kepp O, Rak M, Cai K, Kroemer G, Penninger JM. AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Res. 2019 Jul;29(7):579-591. doi: 10.1038/s41422-019-0181-4.